Saifeixin®
Ceftiofur Injection
 Long-term slow release, one shot last for seven days
No immunosuppression, can be used during viral vaccination
Good tolerance at the injection site



Features                                                                         
Long-term slow release, one shot last for seven days
The ceftiofur hydrochloride crystal combined with the new formulation process ensures the slow release of the active ingredient, and the blood concentration of the drug exceeds 90%. The minimum inhibitory concentration of respiratory pathogens is 168 hours (7 days).
 
Broad spectrum and efficient sterilization, less resistance
It has ideal effects on infections such as Pasteurella multocida, Pasteurella hemolyticus, Actinobacillus pleuropneumoniae, Haemophilus parasuis, Streptococcus, Staphylococcus, Escherichia coli and Salmonella.
Table 1 The minimum inhibitory concentration of Saifeixin in Shandong provinceNote:MIC= minimum inhibitory concentration;MIC50=Minimum inhibitory concentration of 50% bacteria inhibited;MIC90=Minimum inhibitory concentration of 90% bacteria inhibited 90%
 
Safety
The injection site is well tolerated;No adverse reactions have been observed in the injected pigs;No immunosuppression, can be used before and after inoculation of viral vaccine;After the bottle cap is opened, it is still valid when stored at low temperature for 12 weeks.
 
Bioequivalence
Tests have shown that Saficin and its similar products are bioequivalent in pigs. The mean area AUC0-∞ under the plasma concentration-time curve was 369.2±123.7 ug/ml and 385.1±118.9 ug/ml, respectively..

 Figure1. Bioequivalence: The area under the curve of the test preparation (AUC) and the peak concentration of blood (Cmax) reached between 80 and 125% of the original drug.
It can be seen from Fig. 1 that the average AUC0-∞ area under the blood concentration-time curve of Saifisin and the original drug is 369.2±123.7 ug/ml and 385.1±118.9 ug/ml, respectively, and the relative bioavailability is 97.5%. It can be considered that Safeixin is bioequivalent to the original drug.

Table 2  Comparison of Saifin and similar preparations

Saifeixin's application, case on the farm                                                        
A pig farm in Shandong was weaned at 23 days of age. Piglets after weaning showed symptoms of porcine respiratory disease such as rough hair, cough, weight loss, and asthma. The incidence rate was 17%. In the test group, the piglets were injected with Saifeixin on the day of weaning, 0.3 ml per head. The results are as follows:

Table 3. Saifeixin test results* Compared with the control, the average daily weight gain increased by 61 grams; the feed-to-weight ratio decreased by 0.27; the survival rate increased by 8%.
Safeixin's usage                                                                 
One dose only: intramuscular injection at the neck, 5mg/kg body weight, or 1ml/20kg body weight.No more than 2ml per injection site, more than 40kg pigs need more injection sites.
Safeixin medication procedure 


                                                              
For prevention, group health
According to the characteristics of the disease of the farm, it is usually 2 to 3 days before the onset of the disease.
1)7~10 days of age: intramuscular injection 0.2m l/head;
2)Nursery piglets: intramuscular injection 0.3ml/head on weaning day; or intramuscular injection 0.5ml/head 2 weeks after weaning;
3)On PRRS unstable farm: 1 to 2 weeks after weaning, injection of Saifeixin 1ml/20kg body weight.
For individual treatment
When the affected pig is diagnosed as a bacterial infection (or mixed infection) such as streptococcus suis, haemophilus parasuis, actinobacillus pleuropneumoniae or pasteurella multocida, it is immediately injected with 1 ml/20 kg body weight of Safeixin.
Others                                                                            
Traits: gray to gray yellow translucent suspension
Specification: 50ml: 5g
Withdrawal period: pig 4 days
Package: 50ml/bottle×20 bottles/box