Name
Flunixin Meglumine Granules

Ingredients
Flunixin meglumine

Properties
This product is white or light yellow particles.

Pharmacology
Pharmacodynamics
Flunixin meglumine is a potent cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory and anti-rheumatic effects. The analgesic effect is caused by inhibiting the synthesis of peripheral prostaglandins or their hyperalgesic substances or their combined effects, thereby blocking the conduction of pain impulses. The anti-inflammatory effect of peripheral tissues may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursor substances, and inhibiting other mediators to cause local inflammation. Flunixin meglumine does not affect the gastrointestinal motility of horses, but it may improve the hemodynamics of septic shock animals.
                       
Pharmacokinetics
After a single intramuscular injection of pigs (2.2 mg/kg body weight), the plasma elimination half-life is 3 to 4 hours, the peak concentration is 2.94 μg/mL, and the peak time is 0.4 hours. The drug was detected in the blood. The apparent volume of distribution is 2.0 L/kg, and the bioavailability of a single neck injection is 87%.

Medicine interactions
1. Simultaneous use with other non-steroidal anti-inflammatory drugs will aggravate the toxic and side effects on the gastrointestinal tract, such as ulcers and bleeding.
2. Due to the high plasma protein binding rate, when used in combination with other drugs, flunixin meglumine may replace other drugs bound to plasma proteins or be replaced by other drugs itself, so that the replaced drugs have enhanced effects and even toxicity .

Function and Use
Antipyretic and analgesic anti-inflammatory drugs. Used for fever, inflammatory disease, muscle pain and soft tissue pain in livestock and small animals.

Usage and Dosage
Based on this product. Oral administration: One dose, 40 mg per 1 kg of body weight, for dogs and cats, 1-2 times a day for no more than 5 days.

Adverse reactions
Long-term high-dose use of this product may cause animal gastric ulcer and renal function damage.

Precautions
1. Use with caution in animals suffering from peptic ulcer.
2. Do not use it with other non-steroidal anti-inflammatory drugs.

Withdrawal period
No need to formulate.

Specification
According to C14H11F3N2O2 5%

Package
100g/bag

Storage
Shading, keep tightly closed.

Approval No.163322104