According to research conducted by the University of Reading, the addition of oregano essential oil to calf diets can significantly reduce the level of E. coli that is resistant to the fourth-generation cephalosporin antibiotics.

University researchers Dr. Partha Ray and Dr. Caroline Rymer conducted an experiment to determine the effect of supplementing Anpario’s Orego-Stim Liquid (a source of 100% natural oregano essential oil) in waste milk fed to dairy cows on the amount of antibiotics. Affect drug-resistant bacteria in feces. Holstein bulls were provided with waste milk treated with Orego-Stim Liquid for 10 days, or a control diet of the same waste milk source without Orego-Stim Liquid. After the first 10 days, all calves are fed the same proportions of untreated waste milk and concentrated milk until weaning.

Supplementing oregano essential oil not only reduces the number of cefquino-resistant E. coli, but also delays the emergence of cefquino-resistant,"-Dr. Partha Ray.

The results of this study are very promising and provide a potential solution to help reduce the presence of antimicrobial bacteria. In the feces of calves fed with waste milk without Orego-Stim, 44.1% of Escherichia coli were resistant to the cephalosporin antibiotic (Cefquinol). However, in calves fed waste milk supplemented with Orego-Stim Liquid before the 10th day, this was significantly reduced to 12.6% of the total number of E. coli resistant to cefquinol.

More hopefully, resistance to the vital cefquinol is reduced,"-Dr. Caroline Rymer.

"Supplementing oregano essential oil not only reduced the number of cefquino-resistant E. coli, but also delayed the emergence of cefquino-resistant," said Dr. Partha Ray, a lecturer in dairy animal science at the University of Reading. "We are conducting further research to understand the underlying mechanism of the impact of Orego-Stim feeding on the intestinal antimicrobial resistance of young cattle. Improving our understanding of this mechanism is that we improve the feeding practices of essential oil-based supplements to enable It’s the only way to be more sustainable."

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Feed supplements with antimicrobial activity may themselves promote the development of antimicrobial resistance. Therefore, it is very gratifying that there is no evidence that feeding Orego-Stim increases the resistance of E. coli to any of the antibiotic classes tested. Dr. Caroline Rymer, associate professor of animal science at the University of Reading, said: “It is more promising to reduce resistance to the vital cefquinol.”