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Elanco's Industry Voice | July 20, 2018

In order to effectively alleviate bovine respiratory disease (BRD) through a back-up prevention plan, it is important to evaluate the potential risk of the disease and the weight change of the cattle to select the correct dose. 

Micotil® (Tilmicosin Injection) Flex offers a dose range of 1.5 to 3 mL/cwt, which means you can adjust the therapeutic dose to best meet the needs of your cattle. 

Elanco Technical Consultant, DVM Dr. DVM Dr. Jacob Hagenmaier said: "When determining the most appropriate allergy dose, factors such as unknown sources and vaccination history, mixing, severe weather, and nutritional levels should be considered." "As more Risk factors are starting to come into play, and higher doses may be required."

Micotil has more than 25 years of proven results and is used in more than 100 million cattle. It is the only approved macrolide drug with a flexible dosage range in the BRD market. This allows the feedlot not only to adjust the dose according to the risk, but also to consider the weight change of a group of cattle. 

Elanco conducted two flexible dose studies-one in Texas1 and the other in Colorado2-comparing 3 and 1.5 mL/cwt doses (20 mg/kg and 10 mg/kg, respectively) effect.

According to Hagenmaier, taken together, the results of these studies are a good example of how increased doses can benefit certain herds at higher risk of BRD. 

"In these two studies, based on the level of mortality observed, the BRD challenge in the Texas study was even greater. This is also where the 3.0 mL/cwt Micotil dose resulted in a lower dose compared with the low dose in this study. BRD pull rate," he said. "However, regardless of the location and dose, the BRD pull rate of all cattle that received Micotil was reduced compared to the negative control."

In the Texas study, cattle that received Micotil after-effect treatment also brought a higher net return per capita at the end. Compared with untreated controls, cattle given 3.0 or 1.5 mL/cwt Micotil had an advantage of $126.02 and $86.60, respectively. 1

To learn more about how Micotil adapts to customer agreements, please consult your Elanco sales representative or technical consultant. 

Micotil is used to treat bovine respiratory diseases (BRD) related to Mannheimia hemolyticus, Pasteurella multocida, and Haemophilus sleepus, and to control the high risk of BRD related to Mannheimia hemolyticus Respiratory diseases of cattle. 

Before using this product, be sure to read the entire product manual, including the framed human body warning.

Note: Federal (U.S.) law restricts this drug from being used by or in compliance with a licensed veterinarian. Not for human use. Injection of this drug in humans can cause death. Please keep this product out of reach of children. Do not use in auto-powered syringes. Take extra care to avoid accidental self-injection. In the case of human injection, consult a doctor immediately and apply ice or cold compress to the injection site, and avoid direct contact with the skin. Avoid contact with eyes. Always use the correct medication handling and all injection products before administration. Only used for cattle or sheep. Subcutaneous injection. The injection of this antibiotic has been shown to be fatal to pigs and non-human primates, and potentially fatal to horses and goats. Do not use for lambs weighing less than 15 kg. Do not use in female cows that are 20 months old or older. Used in lactating cows or sheep may cause milk residue. The following adverse reactions have been reported: in cattle: swelling and inflammation at the injection site, claudication, collapse, allergic/anaphylactic reactions, reduced food and water consumption, and death; sheep: difficulty breathing and death. Micotil has a 42-day withdrawal period before slaughter. 

Elanco supports the use of shared antibiotics for treatment under the supervision of a veterinarian. For more detailed information on Elanco's antibiotics, benefits and sustainability policies, please visit https://www.elanco.com/our-responsibility#responsible-use-of-antibiotics. 

1Elanco animal health. File information. 2Elanco animal health. File information. 

Micotil, Alanco, and the slash mark are trademarks of Elanco or its affiliates. ©2018 Elanco or its affiliates. pghlth 10876-1 USBBUMIC00162

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