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Researchers have found that ceftiofur cannot effectively penetrate the placenta, making it unable to effectively treat placenta.
Published by Alexandra Beckstett, Editor-in-Chief of The Horse | January 31, 2015 | AAEP Convention, AAEP Convention 2014, Articles, Medicines, Placenta, Veterinary Practice
Placenta is an inflammation of the placenta caused by bacteria such as Streptococcus equi subsp. zooepidemicus. It is one of the main causes of death in foals. Treatment is challenging, and researchers are still struggling to find effective therapies, especially antibiotics. Currently, many practitioners use the antibiotic ceftiofur crystal free acid (CCFA, trade name Excede), but this drug does not penetrate the placenta well. A group of researchers speculated that its oil-based carrier might be the culprit and tested another form of ceftiofur-ceftiofur sodium (trade name Naxcel).
"We assume that ceftiofur sodium will pass the fetal placental barrier," said Margo Macpherson of DVM, MS, and Dipl. ACT, Professor of Large Animal Reproduction, University of Florida School of Veterinary Medicine, Gainesville. She presented the results of the research at the 2014 American Horse Industry Practitioners Association Conference held in Salt Lake City, Utah from December 6th to 10th.
In this study, Macpherson and colleagues injected ceftiofur sodium into six and five healthy pregnant ponies at the commonly used low-dose (2.2 mg/kg) or high-dose (4.4 mg/kg), respectively. Mares range from the 270th day to the 326th day of gestation. The researchers collected 8 plasma samples at various time points up to 24 hours after the administration of ceftiofur to determine its pharmacokinetics (how drug levels are processed and maintained in the body).
The researchers then used eight mares in the second part of the study. Each mare received 4.4 mg/kg ceftiofur sodium per day for three consecutive days, at this time res
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Alexandra Beckstett, the editor-in-chief of The Horse, is a native of Houston, Texas. She is a lifelong horse owner who has succeeded in the National Hunter/Vaulting Tour. , And set foot in hunter breeding. After graduating from Duke University, before joining The Horse, she joined Blood-Horse Publications as an assistant editor for its book department, Eclipse Press.
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