Anti-paining API Levobupivacaine hydrochloride/ Levobupivacaine Powder Local Anesthesia
Levobupivacaine hydrochloride Basic Info.
Synonyms: TIMTEC-BB SBB001337;(S)-(-)-BUPIVACAINE HCL;(S)-(-)-BUPIVACAINE HYDROCHLORIDE;(S)-(-)-1-N-BUTYL-2',6'-DIMETHYL-2-PIPERIDINCARBOXANILID HYDROCHLORIDE;(S)-(-)-1-BUTYL-2-(2,6-XYLYLCARBAMOYL)-PIPERIDINE HYDROCHLORIDE;s-(-)-1-butyl-2',6'-pipecoloxylidide hydrochloride;(s)-1-butyl-2',6'-piperidinecarboxamidemonohydrochloride;(s)-1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamidemonohydrochloride
CAS: 27262-48-2
MF: C18H29ClN2O
MW: 324.89
Chemical Properties:white crystalline powder
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Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine. Bupivacaine is an amide-type local anaesthetic. Although it blocks neuro transmission, its membrane stabilising action also affects the myocardium. This can cause fatal cardiotoxicity. As bupivacaine is widely used in surgery and obstetrics, attempts have been made to develop a safer long-acting local anaesthetic.
The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.
Levobupivacaine Hydrochloride use
Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.
Levobupivacaine Hydrochloride Indications
Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.
Levobupivacaine Hydrochloride Contraindications
Levobupivacaine is contraindicated for IV regional anaesthesia (IVRA).
Levobupivacaine Hydrochloride Adverse effects
Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur.
Systemic exposure to excessive quantities of bupivacaine mainly result in central nervous system (CNS) and cardiovascular effects - CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures) followed by depression (drowsiness, loss of consciousness, respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest - some of which may be due to hypoxemia secondary to respiratory depression.
Anti-paining API Levobupivacaine hydrochloride/ Levobupivacaine Powder Local Anesthesia
Price:
Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference.
Payment methods:
Wire Transfer, Western Union,
We will supply the receiver's information or the bank account information for payment use.
Shipping items:
Shipping items will be delivered by international express like EMS, TNT, UPS, FEDEX or DHL after receiving received.
Every item will be shipped out in 2-3 working days after the payment is done.
The product usually arrives in 4-10 days based on the different destination, and online track is provided.
Please kindly supply the company name, shipping address, contact and tel number for successful shipment.
Mix Order and Drop Shipping:
Mix order service and drop shipping service are available with us. You can choice several items of our products and request us send them in one mixed order.
Regarding drop shipping, we can arrange delivery according your request and do not supply any of our factory information for your safety sales network.
Storage:
Keep away from fire and heat source, hermetically deposit, keep in shady, cool and dry condition, protect against the tide.
Feedback:
We strive on make our customer satisfaction. Once received the products, please kindly give us a feedback so we can keep improving our products and service.
Should you have any problem, please let us know so we can work out with our joint efforts.
Levobupivacaine hydrochloride Basic Info.
Synonyms: TIMTEC-BB SBB001337;(S)-(-)-BUPIVACAINE HCL;(S)-(-)-BUPIVACAINE HYDROCHLORIDE;(S)-(-)-1-N-BUTYL-2',6'-DIMETHYL-2-PIPERIDINCARBOXANILID HYDROCHLORIDE;(S)-(-)-1-BUTYL-2-(2,6-XYLYLCARBAMOYL)-PIPERIDINE HYDROCHLORIDE;s-(-)-1-butyl-2',6'-pipecoloxylidide hydrochloride;(s)-1-butyl-2',6'-piperidinecarboxamidemonohydrochloride;(s)-1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamidemonohydrochloride
CAS: 27262-48-2
MF: C18H29ClN2O
MW: 324.89
Chemical Properties:white crystalline powder
******************************************************************************************
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine. Bupivacaine is an amide-type local anaesthetic. Although it blocks neuro transmission, its membrane stabilising action also affects the myocardium. This can cause fatal cardiotoxicity. As bupivacaine is widely used in surgery and obstetrics, attempts have been made to develop a safer long-acting local anaesthetic.
The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.
Levobupivacaine Hydrochloride use
Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.
Levobupivacaine Hydrochloride Indications
Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.
Levobupivacaine Hydrochloride Contraindications
Levobupivacaine is contraindicated for IV regional anaesthesia (IVRA).
Levobupivacaine Hydrochloride Adverse effects
Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur.
Systemic exposure to excessive quantities of bupivacaine mainly result in central nervous system (CNS) and cardiovascular effects - CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures) followed by depression (drowsiness, loss of consciousness, respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest - some of which may be due to hypoxemia secondary to respiratory depression.
Anti-paining API Levobupivacaine hydrochloride/ Levobupivacaine Powder Local Anesthesia
| Local Anesthetic List | |||
| Products | CAS | Purity | Usage |
| Lidocaine HCI | 73-78-9 | 99 | Release pain |
| Lidocaine | 137-58-6 | 99 | Release pain |
| Tetracaine HCI | 136-47-0 | 99 | Release pain |
| Tetracaine | 94-24-6 | 99 | Release pain |
| Benzocaine 20-40mesh | 94-09-7 | 99 | Release pain |
| Benzocaine 200mesh | 94-09-7 | 99 | Release pain |
| Trimecaine HCl | 1027-14-1 | 99 | Release pain |
| Proparacaine HCI | 5875-06-9 | 99 | Release pain |
| Mepivacaine | 1722-62-9 | 99 | Release pain |
| Cinchocaine HCl | 61-12-1 | 99 | Release pain |
| Articaine HCl | 23964-57-0 | 99 | Release pain |
| Levobupivacaine HCl | 27262-48-2 | 99 | Release pain |
| Bupivacaine HCl | 2180-92-9 | 99 | Release pain |
| Ropivacaine HCl | 132112-35-7 | 99 | Release pain |
Price:
Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference.
Payment methods:
Wire Transfer, Western Union,
We will supply the receiver's information or the bank account information for payment use.
Shipping items:
Shipping items will be delivered by international express like EMS, TNT, UPS, FEDEX or DHL after receiving received.
Every item will be shipped out in 2-3 working days after the payment is done.
The product usually arrives in 4-10 days based on the different destination, and online track is provided.
Please kindly supply the company name, shipping address, contact and tel number for successful shipment.
Mix Order and Drop Shipping:
Mix order service and drop shipping service are available with us. You can choice several items of our products and request us send them in one mixed order.
Regarding drop shipping, we can arrange delivery according your request and do not supply any of our factory information for your safety sales network.
Storage:
Keep away from fire and heat source, hermetically deposit, keep in shady, cool and dry condition, protect against the tide.
Feedback:
We strive on make our customer satisfaction. Once received the products, please kindly give us a feedback so we can keep improving our products and service.
Should you have any problem, please let us know so we can work out with our joint efforts.